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Mannose Health Benefits




Normally, sugar and cancer go together in a negative way. Because a growing number of studies show sugar feeds cancer1,2,3,4 and plays a role in most chronic disease,5 I typically advise you eliminate refined sugar from your diet. I also recommend you limit your fructose consumption for similar reasons. Even when consumed in the form of whole fruit, fructose may be harmful to your health if eaten excessively.

Now, research out of Scotland suggests a type of sugar called mannose, found in cranberries and other fruits, may be useful in the treatment of certain cancers. In experiments involving lab mice, mannose was shown to interfere with the ability of cancerous tumors to take up glucose. It also boosted the effectiveness of chemotherapy drugs.

Mannose Shown to Suppress Cancer in Lab Mice

While sugar has been shown to fuel cancer growth, a team of European researchers, most of whom represent the Cancer Research UK Beatson Institute for Cancer Research at Scotland’s University of Glasgow, have found quite the opposite.

In experiments involving lab mice, Kevin Ryan, Ph.D., professor of molecular cell biology at the University of Glasgow, and his colleagues found mannose:6,7,8

  • Slowed the growth of multiple cancers, including lung, pancreatic and skin, presumably by interfering with the ability of cancerous tumors to take up glucose
  • Reduced the size of cancerous tumors
  • Boosted the effectiveness of cancer drugs — specifically cisplatin and doxorubicin, two of the most widely used chemotherapy medications
  • Did not affect the weight or health of the mice

Mannose also increased the life span of some of the mice. The results of their research were published in the November 2018 issue of the journal Nature.9 To date, mannose has been used as a natural treatment for cystitis (inflammation of the bladder) and urinary tract infections (UTIs).

After Ryan and his team added mannose to the drinking water of mice suffering from lung, pancreatic or skin cancer, they noticed tumor growth slowed. In addition, they noted no obvious side effects to the mice treated with mannose.

“Tumors need a lot of glucose to grow, so limiting the amount they can use should slow cancer progression,” said Ryan. “The problem is that normal tissues need glucose, as well, so we can’t completely remove it from the body.”10

As such, the researchers had to find a dose of mannose sufficient to block glucose such that it slowed tumor growth, but allowed normal tissues to remain unaffected. “This is early research, but it is hoped that finding this perfect balance means that, in the future, mannose could be given to cancer patients to enhance chemotherapy without damaging their overall health,” Ryan stated.11

Beyond the cancers mentioned above, the team exposed cells from other types of cancer — including bone, bowel, leukemia and ovarian — to mannose. Some of the cancer cells responded well to mannose while others did not. About this, one source noted, “The anticancer potential of mannose appeared to depend on whether an enzyme that breaks down the sugar was present in cells.”12

Should You Use Cranberry Juice to Treat UTIs or Cancer?

Very likely you’ve been told that drinking cranberry juice can soothe cystitis and UTIs. Now, the current research seems to suggest it can be used to treat cancer. As such, you may be thinking about loading up on cranberry juice, which I do not recommend.

First, while the use of mannose to treat bladder and urinary tract issues is well founded, I advise you to avoid cranberry juice as a medical treatment. That’s because you’d have to drink a lot of juice, which is often laden with toxic amounts of sugar.

For those conditions, consult your medical practitioner to ensure an accurate diagnosis and then inquire about the possible use of a mannose-containing supplement. Second, with respect to cancer treatment and mannose, keep in mind this research is preliminary and has yet to be tested on humans.

With respect to that, Ryan commented, “Our next step is investigating why [the] treatment only works in some cells, so that we can [determine] which patients might benefit the most from this approach.” He expressed his desire to see clinical trials begin on mannose “as soon as possible to determine its true potential as a new cancer therapy.”

Martin Ledwick, Cancer Research UK’s head information nurse, joined Ryan in cautioning cancer patients to resist the temptation to self-medicate with mannose. Ledwick said:

“Although these results are very promising for the future of some cancer treatments, this is very early research and has not yet been tested in humans.

Patients should not self-prescribe mannose as there is a real risk of negative side effects that haven’t been tested for yet. It’s important to consult with a doctor before drastically changing your diet or taking new supplements.”

The bottom line is it’s difficult to regulate your body’s glucose levels in a healthy manner through self-experimentation. This is particularly the case if you are dealing with a serious illness like cancer or diabetes. While mannose may be a useful complementary treatment, I also encourage you to:

  • Eat a healthy, whole food diet, which implies avoiding processed foods and sugar, especially soda and sweets
  • Exercise regularly
  • Get at least seven to nine hours of high-quality sleep every night
  • Reach out for or continue receiving treatment from professional health care practitioners who are familiar with your condition and experienced in natural approaches

What Is Mannose and How Does It Work?

As mentioned, mannose is a monosaccharide found in cranberries and other fruits, including apples, blueberries, oranges and peaches. It also resides in vegetables like broccoli, cabbage and green beans.

About this simple sugar, The Clinical Advisor says, “In addition, d-mannose occurs naturally in some cells in the human body and is thought to be a prebiotic, because consumption of d-mannose stimulates and fosters the growth of good bacteria in the digestive tract.”

Beyond its presence in whole foods and your body, mannose also commonly appears in supplement form under the name D-mannose. Although mannose is chemically considered a simple sugar, structurally, it is similar to glucose.

That said, it is absorbed more slowly in your gastrointestinal tract than glucose, which accounts for its lower glycemic index. With respect to this aspect of mannose, The Clinical Advisor notes:

“Compared with actual glucose, which is readily absorbed and has a glycemic index of 100, mannose must first be converted into fructose and then into glucose, significantly blunting the insulin response and reducing its impact on blood sugar levels.

After mannose is absorbed by the gut, it is not stored in the liver like glucose, but is filtered out of the body directly by the kidneys.”

For the experiments in which mannose was given to lab mice afflicted by cancers such as bone, bowel, leukemia and ovarian, mannose was shown to more readily disrupt cells that had lower levels of an enzyme called phosphomannose isomerase (PMI). About the impact of PMI, the study authors stated:

“Cells with low levels of PMI are sensitive to mannose, whereas cells with high levels are resistant. … PMI levels also vary greatly between different patients and different tumor types, indicating that PMI levels could be used as a biomarker to direct the successful administration of mannose. …

[T]he administration of mannose could be a simple, safe and selective therapy in the treatment of cancer, and could be applicable to multiple tumor types.”

Research Validates Mannose for Treating Rare Disease CDG and UTIs

D-mannose has been shown to help in the treatment of a rare disease called carbohydrate-deficient glycoprotein syndrome type 1b (CDG 1b). This condition is passed down through families and is characterized by liver and digestive problems associated with hyperinsulinism and inconstant thrombosis. Beyond that, the condition causes your body’s blood coagulation factors to be decreased.

About CDG 1b and mannose, authors of a 2009 study commented, “In our experience, mannose given orally at least four times per day not only transformed lethal CDG 1b into a treatable disease, but also improved the general condition and digestive symptoms of all reported patients but one.”17

As mentioned, D-mannose is commonly used to prevent and treat UTIs, which are usually caused when E. coli bacteria is transferred from your intestinal tract to your urinary tract. D-mannose is great for UTIs because it attaches to the E. coli bacteria, causing them to stick to each other instead of clinging to the walls of your urinary tract.

Under those conditions, the harmful bacteria can be eliminated from your body during urination. Given the increasing instances of antibiotic resistance, natural remedies for UTIs are imperative.

A 2014 study published in the journal World Journal of Urology found D-mannose powder to be as effective as an antibiotic in treating recurrent UTIs in women. A total of 308 women were divided into three groups:18

  • The first group received 2 grams (g) of D-mannose powder mixed in water daily for six months
  • A second group was given 50 milligrams (mg) of the antibiotic Nitrofurantoin daily
  • The third group was a control group and received no treatment

Of the 98 patients experiencing a recurrent UTI, just 15 percent of them consumed D-mannose, whereas 20 percent took the antibiotic and 61 percent received no treatment.

With respect to the outcomes, the study authors said, “D-mannose powder significantly reduced the risk of recurrent UTI, which was no different from [the] Nitrofurantoin group. More studies will be needed to validate the results … but initial findings show that D-mannose may be useful for UTI prevention.”19

If you have been plagued by recurrent UTIs or bladder inflammation, particularly if you are concerned about antibiotic resistance, now may be the time to talk to your health care practitioner about trying D-mannose. It is generally quite effective for up to 90 percent of UTI cases.

The only exception would be UTIs caused by a bacterium other than E. coli; in that case, you’d be better served to ask your doctor about supplements known to disrupt biofilms.20

Mannose Contributes to the Healing Properties of Aloe Vera

While you probably know aloe vera is beneficial for soothing burns, improving wound healing and inhibiting inflammation, you may not be aware that the major sugar in aloe vera is mannose. In a 1994 study, lab mice receiving 300 mg/kilogram (kg) of mannose-6-phosphate showed improved wound healing compared to those treated with saline controls.

The researchers noted, “This dose also had anti-inflammatory activity.”1` Authors of a 2004 study added, “The clear pulp, also known as inner gel, of [the] Aloe vera L. leaf is widely used in various medical, cosmetic and nutraceutical applications. Many beneficial effects of this plant have been attributed to the polysaccharides present in the pulp.”22

Another source states, “High concentrations of mannan saccharides are available in the gel of aloe plants. Laboratory studies show the effects of glucomannan saccharides signals as they activate the immune response through increased expressions of interleukin-1, interleukin-6 and tumor necrosis factor.”

Cautions About Taking Mannose

While mannose is thought to be well tolerated in most people, I do not recommend supplementing with it if you are pregnant or breastfeeding due to the lack of research validating its safe use. That said, pregnant and breastfeeding moms should be fine consuming mannose-containing foods, assuming it is done in moderation. 

The side effects associated with mannose may include bloating and loose stools. Beyond that, since mannose could make it harder to regulate your blood sugar if you have diabetes, use caution when taking D-mannose supplements if you are diabetic.

While the news about mannose as a potential cancer fighter is encouraging, more research, including clinical trials, is needed to validate its effectiveness. For your safety, always consult a medical professional before taking a new supplement or changing the dosing associated with any of your existing supplements.


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Post-vaccine surge? Michigan’s spring coronavirus case spike close to previous year’s autumn high




(Natural News) The spike in new Wuhan coronavirus infections recorded in Michigan over the spring is similar to a spike seen during the 2020 fall season. According to a Wall Street Journal analysis, the state’s daily coronavirus case count averaged more than 7,000 for almost two weeks – before taking a slight dip to 6,891 on April 20. This echoed similar figures back in November and December 2020, which saw sharp rises in infections for those two months before plunging.

Back in autumn of last year, Michigan averaged more than 7,000 cases per day for a span of 10 days. New infections dropped slightly, then briefly spiked as the December holidays approached. It then fell to the low 1,000s for the succeeding two months – until ascending again in March.

According to University of Michigan internal medicine professor Dr. Vikas Parekh, the sudden increase in new infections could be attributed to several factors. Among the factors he cited was re-openings, which increased people’s interactions and mobility. Parekh said the loosened restrictions contributed to the spread of the highly contagious U.K. B117 variant.

“As the B117 variant spreads nationally, we will likely see other stats [with] their own surges – although I hope none are as bad as Michigan,” the professor remarked. He continued: “The milestone just tells us we are not yet in the clear, especially as we still have large portions of our population who are not vaccinated yet.”

Parekh also expressed optimism over the lower daily caseloads the Great Lakes State reported. He said he believes both cases and hospitalizations have plateaued and will likely decline soon. The professor commented: “[COVID-19] positivity has been declining now for one week, which is usually a leading indicator of case decline.”

Meanwhile, the state cited younger populations and youth sports, such as basketball, wrestling and hockey, to increase new COVID-19 infections. Because of this, Gov. Gretchen Whitmer called to suspend youth sports and indoor dining in the state. She also exhorted high schools to conduct remote class sessions for two weeks to curb the spread of the pathogen.

Michigan still experienced the spike in cases despite having one of the highest vaccination rates in the country

During the opening stages of the U.S.’s immunization drive against COVID-19, Michigan boasted of having one of the highest vaccination rates nationwide. A report by Bridge Michigan even noted the initial “frenzy for vaccines” that “far exceeded the state’s limited supply.” But things have appeared to turn around for Michigan, as it now struggles to reach the 70 percent vaccination rate needed for herd immunity.

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Scottish mom’s legs turn into a pair of “giant blisters” after first dose of AstraZeneca’s coronavirus vaccine




(Natural News) Sarah Beuckmann of Glasgow, Scotland, felt a tingling sensation in her legs and noticed a rash flaring up around her ankles a week after getting her first dose of AstraZeneca’s coronavirus (COVID-19) vaccine on March 18.

She also had flu-like symptoms right after the vaccination.

Beuckmann called her doctor to arrange an appointment the morning she noticed the rash, but by the afternoon her skin was already breaking out into blood-filled blisters. Blisters also appeared on her legs, hands, face, arms and bottom.

“I ended up asking my husband to take me to A&E,” said Beuckmann, referring to “accident and emergency,” the equivalent of an emergency room (ER). “When I got there, my heart rate was sitting at 160bpm, which they were very concerned about. I got put on an ECG machine.”

Doctors determine AstraZeneca’s COVID-19 vaccine triggers the rash

Medics carried out tests for HIV, herpes and other skin conditions to work out what triggered the rash, but all results came back negative. Doctors finally determined that the vaccine caused her rare reaction after carrying out two biopsies.

“Once they found that it was a reaction to the vaccine, they put me on steroids and that really seems to be helping my progress,” said Beuckmann. She had been advised by her doctor not to get the second dose of AstraZeneca’s COVID-19 vaccine because of her reaction.

Beuckmann spent 16 days at Queen Elizabeth University Hospital. She was discharged to recover at home. The 34-year-old mother of one is currently wheelchair-bound due to the bandages on her legs and blisters on the soles of her feet. She may need physiotherapy to help strengthen her leg muscles.

“They are starting to heal and they’re looking a lot better than they were but as the blisters started to get worse, they all sort of merged together,” she said. “I didn’t know what was going on.”

With the blisters merging, her legs have looked like a pair of “giant blisters.” Beuckmann admitted that at one point she feared her legs might have to be amputated.

Dermatologist agrees COVID-19 vaccine causes the blisters

Dr. Emma Wedgeworth, a consultant dermatologist and spokeswoman at the British Skin Foundation, agreed that Beuckmann had likely suffered a reaction to the vaccine.

“Vaccines are designed to activate the immune system. Occasionally people will have quite dramatic activation of their immune systems which, as happened in this case, can manifest in their skin” Wedgeworth told MailOnline. “This poor lady had a very severe reaction, which thankfully is extremely rare.”

It is not clear why Beuckmann, who works in retail, was invited for a vaccine. Scotland’s vaccine rollout was focused on people over the age of 50 when she got vaccinated, although vaccines are available to those who are considered at risk from the virus, or live with someone considered vulnerable.

At least 20 million Briton have had AstraZeneca’s COVID-19 vaccine, which drug regulators say causes a rash in one percent of cases. They say rashes caused by the jab tend to go away within a week.

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Trojan labs? Chinese biotech company offers to build COVID testing labs in six states




In 2012, BGI acquired Complete Genomics, a DNA sequencing company and equipment maker. The funds for the $117.6 million purchase were raised from Chinese venture capitals. The company has expanded its footprint globally. According to its website, BGI conducts business in more than 100 countries and areas and has 11 offices and labs in the U.S.

People are concerned about China’s access to American DNA data

Some said that with Complete Genomics providing an American base, BGI would have access to more DNA samples from Americans, helping it compile a huge database of genetic information. Some also worried about the protection of the genetic information’s privacy.

According to a 2019 report from the U.S.–China Economic and Security Review Commission (USCC), BGI “has formed numerous partnerships with U.S. healthcare providers and research organizations to provide large-scale genetic sequencing to support medical research efforts,”

There are three main reasons why many people in the biotech community and government have expressed concerns about China’s access to American DNA data.

In the “60 Minutes” interview, Evanina discussed the very likely scenario in which Chinese companies would be able to micro-target American individuals and offer customized preventative solutions based on their DNA.

Evanina asked: “Do we want to have another nation systematically eliminate our healthcare services? Are we okay with that as a nation?”

The second concern is that China may use DNA to track and attack American individuals. As the USCC report states: “China could target vulnerabilities in specific individuals brought to light by genomic data or health records. Individuals targeted in such attacks would likely be strategically identified persons, such as diplomats, politicians, high-ranking federal officials or military leadership.”

The third concern is that China may devise bioweapons to target non-Asians. Steven Mosher, president of the Population Research Institute, discussed it in his article “What Will China Do With Your DNA?” published by The Epoch Times in March 2019.

He wrote: “We know that the Asian genome is genetically distinct from the Caucasian and African in many ways. … Would it be possible to bioengineer a very virulent version of, say, smallpox, that was easily transmitted, fatal to other races, but to which the Chinese enjoyed a natural immunity? … Given our present ability to manipulate genomes, if such a bio-weapon can be imagined, it can probably – given enough time and resources – be realized.”

An article from Technocracy said: “China’s aggressive collection of American DNA should be doubly alarming because it can only spell one ultimate outcome: biowarfare. That is, genetically engineering viruses or other diseases that will be selectively harmful to U.S. populations.”

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